Artificial Engineering of Immune Cells for Improved Immunotherapy

Targeting Innate Immune Cells for Immunotherapy

Millennium Institute on Immunology and Immunotherapy, Santiago, Chile Programa de Inmunología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile Centro de Investigaciones Cooperativas en Biociencias (CIC bioGUNE), Bilbao, Spain Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia Departament...

Engineering the immune response to "self" for effective cancer immunotherapy

T cells play a critical role in host defense against viruses, intraand extracellular microbes, and tumors. Because foreign antigen is presented amongst a vast majority of self-antigens, T cells have evolved the unique ability to discriminate “self” from “non-self” with high sensitivity and selectivity, enabling the elimination of foreign pathogens while largely avoiding self-reactivity. However...

Engineering Grp170-based immune modulators for cancer immunotherapy

We have recently demonstrated that glucose-regulated protein 170 (Grp170), a stress-responsive molecular chaperone of the endoplasmic reticulum, can be exploited to stimulate anticancer immunity due to its superior antigen chaperoning and delivering capacity. The immune remodeling of the tumor microenvironment induced by a Grp170-based chaperone leads to immune responses that effectively contro...

Development of Artificial Antigen Presenting Cells for Prostate Cancer Immunotherapy

Immunotherapy with artificial adjuvant vector cells

Both innate and adaptive immunity underpin cancer immunosurveillance. To stimulate both these arms of the immune system, we used allogeneic cells loaded with natural killer T (NKT) cell ligands and expressing tumor-associated antigens, resulting in NKT cell activation, dendritic-cell maturation and ultimately in the elicitation of adaptive T-cell responses. This approach holds great promise for...